16 replies to this topic

[HEAVY HITTER]

does anyone have any experience with Frag.GH? curious about it's fat burning properties.

[bowlcut]

It is not cheap stuff so one has to wonder if beta 2 atagonists or topical creams are better used. That or even running a low dose of test to prevent catabolism while one diets?

[piotr]

sorry if i'm ignorant can someone define to me whats "Frag.GH"?

PIOTR

[Grunt76]

sorry if i'm ignorant can someone define to me whats "Frag.GH"?

PIOTR

This most likely refers to the amino acid sequence from postitions 176 to 191 or 177 to 191 of the 191aa sequence for rhGH. This fragment has been identified as being responsible for gh's fatburning abilities. By injecting just that fragment, it is sought to attain such gentle and side-effect-free fatburning as GH provides.

For more information, it is being researched in clinical studies under the name "AOD9604"...

[piotr]

thanx grunt... seems like the concept is still to be exploited fully...

PIOTR

[minster]

thanx, interesting man!!

[big bad stewbert]

i have used it and can honestly say it does work and works well. 300mcg in the AM pre-WO and 1-200mcg @ night before bed. defintely notice w/ in the first few weeks.

[fred9]

are there some more users of hgh fragment? Really interested in hearing some more replies from other users

[Dartan]

GH Frag 176-191 is gaining attention for its weight loss capabilities. It is a fgagment of the entire chain of human growth hormone and considered to be the part of GH that causes weight loss. Pretty much known as "Frag 176," it is being distributed in the underground markets through selective sources. In general the results from users have been positive, sometimes with roaring positive comments. Still, the proven success of Frag 176 has yet to come under extensive and significant scientific studies. A lot of current users are injecting with slin pins in the stomach area, similar to GH use; some use a slin pin IM in the shoulder. Average dosage is 300 mcg 5 times a week, usually taken in the AM hours.

First Comment:
DEVELOPMENT OF A HUMAN GROWTH HORMONE PEPTIDE ANALOGUE AOD9604 INTO AN ANTI-OBESITY DRUG.
Woei-Jia Jiang, Robert Gianello, Mark Heffernan, Esra Ogru, Roksan Libinaki and Frank Ng, from Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia

Previous studies from our laboratory have identified that a carboxy-terminal fragment of the human growth hormone (hGH), hGH(177-191), is the lipolytic/anti-lipogenic domain of intact hGH [1]. By targeting the key enzymes involved in lipid metabolism, hGH(177-191) is able to increase lipolysis, and decrease lipogenesis in adipose tissue, resulting in reduction of body weight gain in obese rodent models.
In view of its significant clinical potential, the aim of our study is to develop the peptide into a drug for the treatment of human obesity. A series of peptide analogues of hGH(177-191) were designed, synthesized and studied for the structure-activity relationship. Among them, Tyr176-hGH(176-191), coded as AOD9604, was found to be one of the most active analogues and therefore selected as the drug candidate for further development [2]. With the extension on the amino terminus of hGH(177-191) by a single tyrosine residue, AOD9604 not only showed a 54% increase in the in vitro bioactivity but also demonstrate its in vivo bioactivity by reducing the body weight gain in the tested animals after chronic oral administration. Further studies by 2D-NMR indicated that the conformation of AOD9604 is relatively constrained and rigid, which may result in its good stability and therefore its oral bioavailability. Preclinical toxicology of AOD9604 was successfully
completed with no unfavorable side effect observed and the Phase I human clinical trials are currently on-going.

This project is supported by Metabolic Pharmaceuticals Limited, Melbourne, Victoria 3142, Australia. (www. Metabolic.com.au)

Second Comment:
Metabolic's Obesity Drug, AOD9604

Basis for the Technology

Growth hormone occurs naturally in the body and, as its name suggests, is one of the key hormones wihich regulates growth. It also has effects on bone strength, fat metabolism and energy metabolism. It is produced at high levels in children, when growth is important, but the levels gradually decrease in the body in adults as age advances. It is also further reduced in obese individuals, leading to reduced ability to burn fat, among other things. When administered to humans, growth hormone stimulates fat metabolism and causes body fat reduction. This occurs by increased lipolysis (breakdown of fat into basic chemical components), and reduced lipogenesis (reduction of the rate of synthesis of fat from its chemical components), as well as an increase in resting energy expenditure.

However, because growth hormone affects more than just fat metabolism, it cannot be used as an effective anti obesity drug. One major undesirable effect of treatment with growth hormone is resistance to the actions of insulin which may lead to diabetes, at best limiting the dose which may be given. Other unwanted effects are associated with muscle and organ growth which are undesirable in adults and cannot be sustained with long term treatment.

Associate Professor Ng at Monash University and his co-workers established that there is a small region of the growth hormone molecule, less than one tenth of its total size, denoted hGH 177-191, which appears to retain some of the actions of growth hormone, but no longer has any effect on growth or on insulin resistance. The actions retained include the stimulation of fat metabolism and the stimulation of bone turnover (bone strengthening, not bone lengthening). These two activities of growth hormone that are retained in the fragment give rise to its use as a therapeutic for obesity and osteoporosis. Minor changes to this fragment have given rise to the drug now in development for obesity and osteoporosis.
This peptide variant of hGH 177-191 is called AOD9604.


Comparative Advantage
Metabolic believes that AOD9604 has a number of important features which enhance its chance of success and give it a competitive advantage in the current market environment:
AOD9604 acts directly on the metabolism of fat. It is the only drug in advanced clinical development which has affects on fat metabolism as its primary mode of action. This means it is likely to be complementary with many of the other weight loss drugs either on the market or in development, rather than being in competition with them. Other drugs mostly work by restricting calorie intake, either by affecting diet, or by preventing fat absorption.
AOD9604 had a very benign safety and tolerability profile, based on the evidence obtained in human clinical trials to date. This again is in contrast to most other weight loss drugs which have a variety of unpleasant or dangerous side effects.
Previous human trials have suggested weight loss of about 2kgs above placebo, over a three month period. This is similar in amount of effect to most other drugs, many of which have been, are, or are projected to be significant commercial successes. Thus with similar levels of effect, but a cleaner side effect profile, AOD9604 should be very commercially viable, if later stage trials confirm the data seen in trials completed so far.




Some experienced users are using 600 mcg/daily for what they say are far more signicant positive results.

Dartan

[j6237]

I used it for about 8 weeks and I could have used that money..

J

[ajdos]

i have used it and can honestly say it does work and works well. 300mcg in the AM pre-WO and 1-200mcg @ night before bed. defintely notice w/ in the first few weeks.

It works well and I found it to be very effective with a low dose of GH as GH does cause insulin resistance at higher doses- very effective for cutting. I was running 300mcgs pre cardio and then again before bed- very effective IMO I have doen it 3 or 4 times now.

[j6237]

i have used it and can honestly say it does work and works well. 300mcg in the AM pre-WO and 1-200mcg @ night before bed. defintely notice w/ in the first few weeks.

It works well and I found it to be very effective with a low dose of GH as GH does cause insulin resistance at higher doses- very effective for cutting. I was running 300mcgs pre cardio and then again before bed- very effective IMO I have doen it 3 or 4 times now.

Its expensive and not stable IMHO and one cant tell if it woking any better than all the "other " stuff their on..

Just simply for the fact you have no idea if its real or it works.. One article means nothing, imho

J

[wildfiend]

I have tried it, by itself, with other fat burning aids, and while on aas. I notice results every time. I did not see dramatic results but without changing diet or cardio I started to lose more bf, skin seemed to be visually more tighter and more vascular. I have tried it at 500mcg first thing in the morning, 500mcg right before bed, and 300 mcg in am and pm. didnt notice that one way was much better than the others but saw results with all methods

[Thinkbig]

OK, SO A YEAR OR SO LATER, WHATS THE ACTUAL CONSENSUS ON THIS SHIT:

HGH FRAG 176-191.

IS IT WORTH IT, OR WOULD ONE BE BETTER OF DOING 20 MINUTES MORE CARDIO AND BUYING MORE EXTRA-LEAN GROUND BEEF WITH THE MONEY U SAVED...?

[LiLCanada]

This is actually the first time I have heard about this, but I did take about a year off away from everything. I'd like to know more about the results of this also.