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[piotr]

Title: Nicotine Administration Induced Changes in the Gonadal Functions in Male Rats.
Authors: Kavitharaj, N. K., Vijayammal, P. L.
Source:Pharmacology; Jan99, Vol. 58 Issue 1, p2-7, 6p

Abstract: Nicotine is reported to have toxic effects on gonadal functions, in addition to its established role in the pathogenesis of atherosclerosis and lung cancer. So nicotine-induced biochemical changes were studied in liver and testes. Chronic administration of nicotine was found to produce enhanced synthesis of cholesterol, triglycerides, phospholipids and free fatty acids in the liver and testes. The activity of the lipogenic enzymes was high in liver but unaltered in testes. The testosterone and estradiol levels in the serum were lower. As the changes brought about by chronic administration of nicotine were counteracted by mecamylamine, a known inhibitor of nicotine, it was proven that nicotine is having a specific gonadotoxic effect.

PIOTR

[catadrioptic]

I Thank GOD I have never smoked everyday I am alive. Seen 3 people I knew and loved die of lung cancer. I really hate cigarettes with a passion. I cant even stand smelling the crap when Im driving and someone in front of me is smoking and the fumes come into my car.