26 replies to this topic

[Grunt76]

Still an absolutely great recomposition cycle brother.

Can anyone expect any more?

[SoCo4Fun]

Oh believe me mang...I am more than happy with my progress so far...it makes me wicked stoked to see what this bulker will bring!!!

[SoCo4Fun]

On another note...I got my CJC in and start it tonight...test enanthate gets added in soon...

[SoCo4Fun]

The lethargy has been unbearable...I don't know if it's from the CJC or from being shutdown on the epi/hdrol...test gets added in very soon so we'll knwo then...

[Grunt76]

CJC is known to make you lethargic, and so is low-test...

[SoCo4Fun]

Yeah we'll see which one it is once the test e kicks in...

It's so bad that my normal crutch of sugar free Rockstars isn't working...

[Grunt76]

Yeah we'll see which one it is once the test e kicks in...

It's so bad that my normal crutch of sugar free Rockstars isn't working...

IBE's X-Force with a little alcar has been a big boost to me in this regard in the past.

[SoCo4Fun]

Grunt...what are your thoughts on throwing in DHEA? dat just posted this at AM...

Restoration of aging growth hormone cells by dehydroepiandrosterone via estrogen receptors by Iruthayanathan, Mary, Ph.D., University of Arkansas for Medical Sciences, 2004, 136 pages; AAT 3165066

Abstract (Summary)

Dehydroepiandrosterone (DHEA) is the most abundant circulating steroid in humans. With progressive aging there is a decline in the levels of DHEA, growth hormone (GH) and sex steroids. DHEA levels seem to correlate inversely with morbidity and mortality associated with aging. Hence, it is widely used as an anti-aging supplement to counter these effects. DHEA is considered traditionally as a precursor hormone for estrogens and androgens and to have no function of its own, as it does not have a specific receptor. The decline in GH levels with aging is associated with a loss of GH cells (somatotropes) in the pituitary.

The objective of this study was to learn if the functions of somatotropes can be restored in aging female rats (12-14-months and 18-months) to levels seen in young, diestrous rats (3-4 months). Using in vitro and in vivo methods, the results indicate that DHEA acts directly at the level of the pituitary to restore GH gene expression to levels seen in young rats. The study employed cytochemical and molecular techniques (immunocytochemistry, in-situ hybridization, QRT-PCR) to assess the function and gene expression of somatotropes.

This is the first study to our knowledge, to show a loss of GH-releasing hormone-receptor (GHRH-R) binding cells in aging female rat pituitaries, which could also be a contributory factor in the decline of GH levels. Short-term DHEA treatment of 18-month-old rats, in vivo , increases the number of GHRH-binding cells in the pituitary resulting in a two-fold increase in serum GH. The study also addresses mechanisms behind DHEA's restoration of aging somatotropes in vitro using inhibitors (trilostane and aminoglutethemide) that block specific metabolic pathways of DHEA. The study shows that DHEA needs to be aromatized to estrogen to restore GH expression in aging somatotropes. ICI 182,780, an estrogen receptor (ER) antagonist, also blocked the restorative effects of DHEA, suggesting that ERs play a key role in DHEA's action on aging somatotropes. In summary, this study shows that DHEA has direct actions on the pituitary, possibly after aromatization to estrogen. The findings in aging rats suggest that DHEA replacement might benefit individuals with low GH levels.


Advisor: Childs, Gwen V.
School: University of Arkansas for Medical Sciences
School Location: United States -- Arkansas
Keyword(s): Restoration, Aging, Growth hormone, Dehydroepiandrosterone, Estrogen receptors
Source: DAI-B 66/02, p. 658, Aug 2005
Source type: Dissertation
Subjects: Cellular biology
Publication Number: AAT 3165066
ISBN: 9780542002564

[SoCo4Fun]

Strength is way up now...I'm holding a little water but I weighed in this morning at 206 (on an empty stomach)...The lethargy is still killing me...I'm also having a lot of achiness in my wrists and fingers lately.

[SoCo4Fun]

Weighed in at 210.5 this am...Hopefully getting my bodyfat tested this weekend...

[SoCo4Fun]

Test is kicked in and the lethargy is gone...feeling much better! I had my bodyfat tested on tuesday...I was 214@14.5%

Overall I'm very happy with my results so far...strength is still going up...I have a little bloat going on but nothing too bad...I appear to hold water in my gut...my stomach is larger but it's not fat...very weird...I'm not sure if it is from the peptides or just all the food I'm taking in...

[ketsugo]

Fascinating thread, Im about to begin a similiar cycle, bump for an update Bro