6 replies to this topic

[piotr]

Appl Physiol Nutr Metab. 2008 Jun;33(3):470-5.
The effects of ibuprofen on muscle hypertrophy, strength, and soreness during resistance training.
Krentz JR, Quest B, Farthing JP, Quest DW, Chilibeck PD.

High doses of ibuprofen have been shown to inhibit muscle protein synthesis after a bout of resistance exercise. We determined the effect of a moderate dose of ibuprofen (400 mg.d-1) consumed on a daily basis after resistance training on muscle hypertrophy and strength. Twelve males and 6 females (~24 years of age) trained their right and left biceps on alternate days (6 sets of 4-10 repetitions), 5 d.week-1, for 6 weeks. In a counter-balanced, double-blind design, they were randomized to receive 400 mg.d-1 ibuprofen immediately after training their left or right arm, and a placebo after training the opposite arm the following day. Before- and after-training muscle thickness of both biceps was measured using ultrasound and 1 repetition maximum (1 RM) arm curl strength was determined on both arms. Subjects rated their muscle soreness daily. There were time main effects for muscle thickness and strength (p < 0.01). Ibuprofen consumption had no effect on muscle hypertrophy (muscle thickness of biceps for arm receiving ibuprofen: pre 3.63 +/- 0.14, post 3.92 +/- 0.15 cm; and placebo: pre 3.62 +/- 0.15, post 3.90 +/- 0.15 cm) and strength (1 RM of arm receiving ibuprofen: pre 18.6 +/- 2.8, post 23.4 +/- 3.5 kg; and placebo: pre 18.8 +/- 2.8, post 22.8 +/- 3.4 kg). Muscle soreness was elevated during the first week of training only, but was not different between the ibuprofen and placebo arm. We conclude that a moderate dose of ibuprofen ingested after repeated resistance training sessions does not impair muscle hypertrophy or strength and does not affect ratings of muscle soreness.

BUT....

There is research that shows higher than moderate use of NSAIDS reduce PGF2-a and a lot of anecdotal banter that NSAID use retards muscle growth...

I've just copped a nasty wrist injury... i have meloxicam and ibuprofen... i'm planning on taking the meloxicam at 30mg per day for 4 days (is all i have) then 1600mg ibuprofen for a week or so...

any suggestions or comments?

piotr

[Thinkbig]

ACUTE USE OF IBUPROFEN IS PROVEN TO HALT PROTEIN SYNTHESIS N DOTHER CELL ACTIVITIES FOR MUSCLE GROWTH, BUT ITS TEMPORARY I BELIEVE THUSLY ITS THE ACUTE NATURE THAT THE BODY FINDS TROUBLESOME APPARENTLY.

I HAVE READ THAT IBUPROFEN IS ALSO POSSIBLY THE WORST OF THE OPTC NSAIDS TO TAKE IN THAT RESPECT.

THING IS THOUGH, IF ITS BAD ENOUGH TO WARRANT IT I THINK TAKING IT TO HELP DEAL WITH THE IMFLAMMATION WILL HELP MORE THAN THE MILD HALT IN PROTEIN SYNTHESIS WILL HURT.

I WOULDN'T SUGGEST YOU STAY ON THEM FOR VERY LONG.

PERSONALLY I JUST GOT IN A REALLY BAD MOTORCYCLE WRECK AND THEY PRESCRIBED ME ABUNCH OF PAIN MEDS AS WELL AS HAVING ME ON 1600MG OF IBUPROFEN DAILY, I NEVER TOOK THE IBUPROFEN, JUST THE SCRIPT PK'S FOR A FEW DAYS THEN GOT OFF THEM TOO, I'M NOT MUCH FOR THAT TYPE OF SHIT, I'D RATHER JUST HURT, UNLESS ITS UNBEARABLE.

[piotr]

i dont think i'll be on them for more than a week... already today its feeling better... i remember when i fucked a disc in my back i was only on the NSAIDS for like 2 weeks and this is nothing compared to that... bloody heavy close grip bench GETS ME EVERY TIME!!! when will i learn...

piotr

[extremevet]

try it with the ez curl bar

[any1uno]

Interesting article....and I lost my train of thought staring up at Extremevet's AVY...oh my I want her so badly!!! WOW!

Uh...sorry to hear about your accident TB but still one day I'm going to get you for it!!!

[juaneye]

Interesting article....and I lost my train of thought staring up at Extremevet's AVY...oh my I want her so badly!!! WOW!

Uh...sorry to hear about your accident TB but still one day I'm going to get you for it!!!

that's what this thread is about....right?

[piotr]

those tits are WAAY too big... gurgh

piotr